Home > Treatment Recommendations > Adult Patients > Gastrointestinal > Clostridioides (previously Clostridium) difficile infection (CDI) > Initial episode - severe

Initial episode - severe

WBC > 15 x 10⁹/L,
or
rise in serum creatinine to > 130 umol/L

Usual Pathogens

Clostridioides difficile

Empiric Therapy	Dose	Duration
Vancomycin	125mg PO/NG qid	10 days

Vancomycin allergy/intolerance

Empiric Therapy	Dose	Duration
Fidaxomicin	200mg PO bid	10 days