Initial episode - nonsevere

  • WBC < 15 x 109/L,
    and

  • serum creatinine < 130 umol/L

Usual Pathogens

Clostridioides difficile

Low Risk

Empiric Therapy

Dose

Duration
Metronidazole 500mg PO/NG tid 10 days

If NPO for oral medications

Empiric Therapy Dose Duration
Metronidazole IV 500mg IV q8h 10 days

Allergy/intolerance/unresponsive to metronidazole

Empiric Therapy

Dose

Duration
Vancomycin 125mg PO/NG qid

10 days

High risk

Empiric Therapy

Dose

Duration
Vancomycin 125mg PO/NG qid

10 days

Vancomycin allergy/intolerance

Empiric Therapy

Dose

Duration
Fidaxomicin 200mg PO bid

10 days