Necrotizing enterocolitis (NEC)

- Adjust therapy based on Gram stain and/or culture, including antifungal therapy if applicable.

 
Usual Pathogens

Enterobacterales
Streptococcus spp
Coagulase negative Staph

 
Perforation add:

Anaerobes

 

Empiric Therapy

Dose

Duration
Vancomycin 40-60mg/kg/d IV div q6h 7-10 days
+    
Cefotaxime 150-200mg/kg/d IV div q8h  

Perforation

Empiric Therapy Dose Duration
add Metronidazole 30mg/kg/d IV div q12h 7-10 days

Severely ill

Empiric Therapy

Dose

Duration
Meropenem 60mg/kg/d IV div q8h 7-10 days
+    
Vancomycin 40-60mg/kg/d IV div q6h