Early onset (≤ 4 days hospitalization) or Late onset (> 4 days hospitalization)

  • non-ICU
  • no mechanical ventilation
  • no broad-spectrum antibiotics
Usual Pathogens

S. pneumoniae
S. aureus/MRSA
H. influenzae
Enterobacterales

< 3 months old

Empiric Therapy Dose Duration
Cefotaxime 200mg/kg/d IV div q6h 7 days

≥ 3 months old

Empiric Therapy

Dose

Duration
Ceftriaxone 100mg/kg IV q24h

7 days

If MRSA suspected add:

Empiric Therapy

Dose

Duration
Vancomycin 60mg/kg/d IV div q6h Minimum 14 days for confirmed MRSA
or    
Linezolid < 5 years old: 30mg/kg/d IV/PO div q8h Minimum 14 days for confirmed MRSA
  > 5 years old: 20mg/kg/d IV/PO div q12h