Community-acquired

 
Usual Pathogens

Oral anaerobes
Streptococcus spp
Eikenella corrodens

 

Empiric Therapy

Dose

Duration
[Penicillin VK 40mg/kg/d PO div qid or tid 7-14 days
or    
Penicillin G] 150,000-250,000 units/kg/d IV div q6h 7-14 days
+    
Metronidazole IV/PO 30mg/kg/d IV div q12h/15-30mg/kg/d PO div bid  

ß-lactam allergy

Empiric Therapy Dose Duration
Clindamycin IV/PO 20-40mg/kg/d IV div q8h/20-40mg/kg/d PO div qid 7 -14 days