Empyema - hospital-acquired
- Pleural fluid should be tapped ASAP and antibiotics re-assessed if Gram stain positive.
Usual Pathogens
S. aureus/MRSA
S. anginosus group
Enterobacterales
P. aeruginosa
Anaerobes
Enterococcus spp
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 240-300mg piperacillin/kg/d IV div q6-8h | 3 weeks |
| + | ||
| [Vancomycin | 60mg/kg/d IV div q6h | 3 weeks |
| or | ||
| Linezolid] | < 5 years old: 30mg/kg/d IV/PO div q8h | 3 weeks |
| > 5 years old: 20mg/kg/d IV/PO div q12h |