Usual Pathogens
Group B Streptococci
Enterobacterales
Listeria monocytogenes
If VLBW in NICU (particularly with CVL):
Coagulase negative Staph (CoNS)
Candida spp
| Empiric Therapy | Duration | |
|---|---|---|
| Ampicillin | 300mg/kg/d IV div q6h |
Gram positive: ≥ 14 days Gram negative: ≥ 21 days |
| + | ||
| [Gentamicin | 4-5mg/kg IV q24h | |
| or | ||
| Cefotaxime] | 200mg/kg/d IV div q6h |
If failure of above regimen or colonized with cefotaxime-resistant Gram negative or Gram negative grows in blood or CSF cultures
| Empiric Therapy | Duration | |
|---|---|---|
| Meropenem | 90mg/kg/d IV div q8h | Gram positive: ≥ 14 days Gram negative: ≥ 21 days |
| If failure of meropenem or Gram positive cocci grows in blood or CSF cultures, add: | ||
| 45mg/kg/d IV div q8h |
Candida spp
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Amphotericin B | 0.7-1mg/kg IV daily | Min. 2 weeks after resolution of all signs & symptoms |
| +/- | ||
| Flucytosine | 25mg/kg IV/PO qid | |
| Alternative | ||
| Fluconazole | 12mg/kg IV/PO daily | Min. 2 weeks after resolution of all signs & symptoms |