Native valve
- Tailor antibiotic therapy to C&S results. β-lactams superior to vancomycin so preferred if susceptible. If penicillin allergy reported, allergy should be confirmed by an allergist and desensitization considered.
Usual Pathogens
S. aureus/MRSA
Viridans Group Streptococci
Rare:
Enterococcus spp
HACEK organisms
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 60mg/kg/d IV div q6h | See Treatment of Culture-proven Endocarditis in Recommended Therapy of Culture-Directed Infections in Adult Patients. Use pediatric doses (Table A). |
| + | ||
| Ceftriaxone | 100mg/kg IV daily |
Severe penicillin/cephalosporin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 60mg/kg/d IV div q6h | See Treatment of Culture-proven Endocarditis in Recommended Therapy of Culture-Directed Infections in Adult Patients. Use pediatric doses (Table A). |
| + | ||
| Gentamicin | 3mg/kg/d IV div q8h |