Tailor duration of therapy to identified organism and infection. Must be afebrile for at least 48h and neutrophil count > 0.5 x 10⁹/L before discontinuing antibiotic therapy.

• Bacteremia, SSTI, pneumonia - 10-14 days

No focus:

• If neutrophil count ≥ 0.5x10⁹/L – 7 days minimum
• If neutrophil count < 0.5x10⁹/L - 2 weeks minimum

Longer therapy may be required if:

• neutrophil count < 0.1 x 10⁹/L
• severe mucositis
• unstable vital signs