Post-Trauma

- Fulminant onset 2-7 days following penetrating trauma.

- Vitrectomy may be required.

- Consider adjunctive systemic antibiotics.

- Intravitreal dexamethasone 0.4mg/0.1mL may be beneficial.

 
Usual Pathogens

Bacillus cereus
S. epidermidis
Enterobacterales
Pseudomonas spp
Anaerobes
Fungi

Ophthalmic Preparations

Empiric Therapy Dose Duration
Vancomycin 1mg/0.1mL 0.1mL intravitreally Dependent on clinical picture
+    
Ceftazidime 2.25mg/0.1mL 0.1mL intravitreally  

ß-lactam Allergy

Empiric Therapy Dose Duration
Vancomycin 1mg/0.1mL 0.1mL intravitreally Dependent on clinical picture
+    
[Gentamicin 0.2mg/0.1mL 0.1mL intravitreally  
or    
Amikacin 0.4mg/0.1mL] 0.1mL intravitreally