Mucocutaneous
Immunocompetent
Primary (gingivostomatitis)
- Therapy should be started within 72 hours of symptom onset, or at any time if new lesions forming.
- Topical therapy not recommended as ineffective.
Usual Pathogens
Herpes simplex
Mild
| Therapy | Dose | Duration |
|---|---|---|
| None |
Severe
| Therapy | Dose | Duration |
|---|---|---|
| Acyclovir | 40-60mg/kg/d PO div 4-5x/d or | 5-7 days |
| 30mg/kg/d IV div q8h | 5-7 days |
Recurrent (fever blisters, cold sores)
Herpes simplex
No therapy indicated unless recurrences are:
- severe and
- > 6 episodes/year
can give suppressive therapy:
| Therapy | Dose | Duration |
|---|---|---|
| Acyclovir | 40-60mg/kg/d PO div bid-tid |
Immunocompromised
Usual PathogensHerpes simplex
| Therapy | Dose | Duration |
|---|---|---|
| Acyclovir | 40-60mg/kg/d PO div 5x/d or | 7-14 days |
| 30mg/kg/d IV div q8h | 7-14 days |