2° to paranasal sinusitis

- Consider P. aeruginosa in recently hospitalized, instrumented, or immunocompromised patients. Use ceftazidime instead of ceftriaxone.

 
Usual Pathogens

S. pneumoniae
M. catarrhalis
H. influenzae
S. aureus/MRSA
Group A Streptococci
Anaerobes

Paediatric

Empiric Therapy Dose Duration
Cloxacillin 200mg/kg/d IV div q6h 10-14 days
+    
Ceftriaxone 100mg/kg/d IV div q12h  
+/-    
Metronidazole 30mg/kg/d IV div q8h  

Adult

Empiric Therapy Dose Duration
Cloxacillin 2g IV q4h 10-14 days
+    
Ceftriaxone 2g IV q12h  
+    
Metronidazole 500mg IV q8h